Investigating the Y chromosome in complex disease: Phenome-wide scan across 104,334 Finnish men

Abstract excerpt

<h4>ABSTRACT</h4> Although the Y chromosome represents roughly 2% of the male genome, it is often ignored in genome-wide association studies (GWAS). Subsequently, the potential health impacts of Y-chromosomal genetic variation remain incompletely understood. To fill this gap, we performed a phenome-wide association study (PheWAS) in FinnGen across 1,426 binary and quantitative traits using Y-chromosomal variation...

Topics

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• Chromosomes, Human, Y
• Genetic Association Studies
• Genetics, Population
• Molecular Epidemiology
• Multifactorial Inheritance
• Quantitative Trait Loci
• Recombination, Genetic
• Sex Determination Processes

Identifiers and source

Literature Corpus work

82ca2acd-005c-5fe9-9b47-b245fb8dec2e

DOI

10.64898/2026.06.09.26355235