Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of X chromosome and dosage-compensation mechanisms in complex trait genetics.

American journal of human genetics - 5 Jun 2025

Fu Yu, Kenttämies Aino, Ruotsalainen Sanni, Pirinen Matti, Tukiainen Taru

Abstract excerpt

The X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX on human complex traits remains debated. Here, we systematically assessed the relevance of chrX and the effect of its biology on complex traits by analyzing 48 quantitative traits in 343,695 individuals in UK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Height
Share to Chromosomes, Human, X
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Quantitative Trait, Heritable

Share to Quantitative Trait Loci

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 40359939
DOI: 10.1016/j.ajhg.2025.04.004
PMCID: PMC12256796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of X chromosome and dosage-compensation mechanisms in complex trait genetics.PMID 40359939Read ↗

Role of X chromosome and dosage compensation mechanisms in complex trait geneticsSemantic proximity Read ↗

The effect of X-linked dosage compensation on complex trait variationSemantic proximity Read ↗

Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.Semantic proximity Read ↗

geneXplore: An Interactive Browser for X Chromosome-Wide Association Study ResultsSemantic proximity Read ↗

GXwasR: A Toolkit for Investigating Sex-Differentiated Genetic Effects on Complex TraitsSemantic proximity Read ↗

How to include chromosome X in your genome-wide association study.Semantic proximity Read ↗

The pivotal role of the X-chromosome in the genetic architecture of the human brainSemantic proximity Read ↗

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structureSemantic proximity Read ↗

Investigating the Y chromosome in complex disease: Phenome-wide scan across 104,334 Finnish menSemantic proximity Read ↗

Amplification is the Primary Mode of Gene-by-Sex Interaction in Complex Human TraitsSemantic proximity Read ↗

Combinatorial effects of gene dosage, polygenic background and environment on complex traitsSemantic proximity Read ↗

The X factor: A robust and powerful approach to X-chromosome-inclusive whole-genome association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.