Article

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

2020-04-25

Abstract excerpt

<h4>SUMMARY</h4> Coronaviruses (CoVs) emerge as zoonoses and cause severe disease in humans, demonstrated by the SARS-CoV-2 (COVID-19) pandemic. RNA recombination is required during normal CoV replication for subgenomic mRNA (sgmRNA) synthesis and generates defective viral genomes (DVGs) of unknown function. However, the determinants and patterns of CoV recombination are unknown. Here, we show that divergent β-Co...

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Literature Corpus work: 5f7d124e-e3c0-55fc-90ee-22e8dfc9ea33
DOI: 10.1101/2020.04.23.057786

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