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Article

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

14 Feb 2022

Abstract excerpt

High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3'-to-5' exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises nucleotides including antiviral drugs misincorporated by the low-fidelity viral RNA-dependent RNA polymerase (RdRp) and has also been implicated in viral RNA recombination and resistance to innate immunity. Here, we determined a 1.6-Å...

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PMID: 35165203
DOI: 10.1073/pnas.2106379119

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