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Article

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

Journal of virology - 1 Nov 2007

Eckerle Lance D, Lu Xiaotao, Sperry Steven M, Choi Leena, Denison Mark R

Abstract excerpt

Replication fidelity of RNA virus genomes is constrained by the opposing necessities of generating sufficient diversity for adaptation and maintaining genetic stability, but it is unclear how the largest viral RNA genomes have evolved and are maintained under these constraints. A coronavirus (CoV) nonstructural protein, nsp14, contains conserved active-site motifs of cellular exonucleases, including DNA...

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Share to Cricetinae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17804504
DOI: 10.1128/JVI.01296-07
PMCID: PMC2169014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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