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SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitness

2024-11-13

Abstract excerpt

Coronaviruses (CoVs) maintain large RNA genomes that frequently undergoes mutations and recombination, contributing to their evolution and emergence. In this study, we find that SARS-CoV-2 has greater RNA recombination frequency than other human CoVs. In addition, coronavirus RNA recombination primarily occurs at uridine (U)-enriched RNA sequences. Therefore, we next evaluated the role of SARS-CoV-2 NSP15, a viral...

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Literature Corpus work
4c7b45aa-0be6-5d50-a71b-7bf511a8b027
DOI
10.1101/2024.11.11.622995
Open publication

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SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitnessDOI 10.1101/2024.11.11.622995
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