Article

Structural and functional studies of human methionine adenosyltransferases

2015-01-01

Abstract excerpt

S-Adenosylmethionine (SAMe) is the principal methyl donor of the cell and is synthesized via an ATP-driven process by methionine adenosyltransferase (MAT) enzymes. It is tightly linked with cell proliferation in liver and colon cancer. In humans, there are three genes, MAT1A, MAT2A and MAT2B, which encode MAT enzymes. MAT2A and MAT2B transcribe MATα2 and MATβ enzyme subunits, respectively, with catalytic and regul...

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Literature Corpus work: 5f77fdd2-e6e4-5825-ae2e-f65ada9e02c9
DOI: 10.17638/02046880

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