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Article

Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.

Gastroenterology - 1 Apr 2003

Martínez-Chantar Maria L, García-Trevijano Elena R, Latasa M Ujue, Martín-Duce Antonio, Fortes Puri, Caballería Juan, Avila Matías A, Mato José M

Abstract excerpt

BACKGROUND & AIMS: Of the 2 genes (MAT1A, MAT2A) encoding methionine adenosyltransferase, the enzyme that synthesizes S-adenosylmethionine, MAT1A, is expressed in liver, whereas MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. Here, we identified the beta subunit as a regulator of proliferation in human hepatoma cell lines. The beta...

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Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Cirrhosis

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Source

Identifiers

PMID: 12671891
DOI: 10.1053/gast.2003.50151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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