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Article

Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2011

Nordgren Kendra K S, Peng Yi, Pelleymounter Linda L, Moon Irene, Abo Ryan, Feng Qiping, Eckloff Bruce, Yee Vivien C, Wieben Eric, Weinshilboum Richard M

Abstract excerpt

Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the major biological methyl donor. MAT1A and MAT2A encode two distinct MAT isoforms in mammals. MAT2A is expressed in nonhepatic tissues, whereas MAT1A is expressed in the liver. A third gene, MAT2B, encodes a MAT2A regulatory protein. We resequenced MAT2A and MAT2B exons, splice junctions, and flanking regions using 288 DNA...

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Identifiers

PMID: 21813468
DOI: 10.1124/dmd.111.040857
PMCID: PMC3198898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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