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Article

The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site.

Journal of molecular biology - 7 Jul 2000

González B, Pajares M A, Hermoso J A, Alvarez L, Garrido F, Sufrin J R, Sanz-Aparicio J

Abstract excerpt

Most of the transmethylation reactions use the same methyl donor, S-adenosylmethionine (SAM), that is synthesised from methionine and ATP by methionine adenosyltransferase (MAT). In mammals, two MAT enzymes have been detected, one ubiquitous and another liver specific. The liver enzyme exists in two oligomeric forms, a tetramer (MAT I) and a dimer (MAT III), MAT I being the one that shows a higher level of...

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PMID: 10873471
DOI: 10.1006/jmbi.2000.3858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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