Article

Methionine adenosyltransferase structure and function studies : the novel role of a gating loop and a disease-causing residue in enzyme catalysis

2020-01-01

Abstract excerpt

Methylation is an underpinning process of life and provides control for biological processes such as DNA synthesis, cell growth and apoptosis. Methionine Adenosyltransferases (MAT) produce the cellular methyl donor, S-Adenosylmethionine (SAMe). Dysregulation of SAMe levels is a relevant event in many diseases including cancers such as hepatocellular carcinoma and colon cancer. In addition, MAT deficiency causes is...

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Literature Corpus work: a56c367a-0686-5d71-88e6-dd3690f03938
DOI: 10.17638/03088317

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