Article

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis

2020-03-26

Abstract excerpt

The cerebral microvasculature is essential for preservation of normal cerebral function. Age-related decreases of neurogenesis and cognitive function are accompanied by reduced blood flow and a decline in neural stem cell (NSC) number. Here, we report that metformin administered by tail vein injection enhanced cognition in aged but not young mice in a dose-dependent manner. Further, metformin restored cerebral blo...

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Literature Corpus work: 59491759-6659-530a-874c-ece074a03de7
DOI: 10.1101/2020.03.25.006767

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