Characterizing spatial functional microniches with SpaceTravLR

Abstract excerpt

The advent of spatial omics has revolutionized our understanding of tissue biology; however, these technologies remain largely descriptive and do not capture how changes in gene regulation propagate across spatial neighborhoods. While in-silico perturbation methods and foundation models aim to model the impact of genetic perturbations, these methods are limited to single-cell approaches that lack spatial resoluti...

Topics

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• IL-33, ST2, and ILC Pathways
• Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Neonatal Respiratory Health Research

Identifiers and source

Literature Corpus work

4cead2e7-3ab4-56e7-bc94-67f072d5d615

DOI

10.1101/2025.11.13.688264