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Spatially Resolved Transcriptomics: Revealing Tumor Microenvironment Heterogeneity to Advance Cancer Immunotherapy

4 Sept 2025

Abstract excerpt

Despite the availability of numerous approved immunotherapies for various cancers, durable progression-free survival remains relatively uncommon among patients with advanced cancer. As research into immunotherapy intensifies, the heterogeneity and complexity of the tumor microenvironment (TME) have emerged as critical determinants of treatment response and a major obstacle to understanding tumor resistance...

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PMID: 40908733
DOI: 10.1002/smtd.202500770

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