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Article

Endocrine resistance in hormone-responsive breast cancer: mechanisms and therapeutic strategies.

Endocrine-related cancer - 1 Aug 2016

Murphy Conleth G, Dickler Maura N

Abstract excerpt

The majority of breast cancers may be considered hormone responsive due to expression of hormone receptors (HR+). Although endocrine therapy is always considered for advanced HR+ breast cancer, the emergence of resistance is inevitable over time and is present from the start in a proportion of patients. In this review, we explore the mechanisms underlying de novo and acquired resistance to endocrine therapy. We...

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Identifiers

PMID: 27406875
DOI: 10.1530/ERC-16-0121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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