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Article

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis.

Nature communications - 9 Jun 2021

Singh Meetali, Cornes Eric, Li Blaise, Quarato Piergiuseppe, Bourdon Loan, Dingli Florent, Loew Damarys, Proccacia Simone, Cecere Germano

Abstract excerpt

In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their essential functions for animal fertility and embryonic development, how CSR-1 22G-RNAs are produced remains unknown. Here, we show that CSR-1 slicer activity is primarily involved in triggering the synthesis of small RNAs on the coding sequences...

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Identifiers

PMID: 34108460
DOI: 10.1038/s41467-021-23615-w
PMCID: PMC8190271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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