Article

BRAFV600E Expression in Mouse Neuroglial Progenitors Increase Neuronal Excitability, Cause Appearance of Balloon-like cells, Neuronal Mislocalization, and Inflammatory Immune response

2019-02-08

Abstract excerpt

<h4>BACKGROUND</h4> Frequent de-novo somatic mutations in major components (PI3KCA, AKT3, TSC1, TSC2, mTOR, BRAF) of molecular pathways crucial for cell differentiation, proliferation, growth and migration (mTOR, MAPK) has been previously implicated in malformations of cortical development (MCDs) and low-grade neuroepithelial tumors (LNETs) 1–7 . LNETs are the most frequent tumors found in patients undergoing r...

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Literature Corpus work: 5f031b94-0a09-5bc0-bf0f-0057a2ee1509
DOI: 10.1101/544973

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