Article

Heterogeneity and excitability of <i>BRAF</i> <sup> <i>V600E</i> </sup> -induced tumors is determined by PI3K/mTOR-signaling state and <i>Trp53</i> -loss

2021-02-22

Abstract excerpt

<h4>Background</h4> Developmental brain tumors harboring BRAF V600E somatic mutation are diverse. Here, we describe molecular factors that determine BRAF V600E -induced tumor biology and function. <h4>Methods</h4> Intraventricular in utero electroporation in combination with the piggyBac transposon system is employed as a tool to generate developmental brain neoplasms. In vivo tumor growth is monitored by u...

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Literature Corpus work: 4b831b7d-9f6d-5b00-aa49-135032bd8e64
DOI: 10.1101/2021.02.22.432030

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Heterogeneity and excitability of <i>BRAF</i> <sup> <i>V600E</i> </sup> -induced tumors is determined by PI3K/mTOR-signaling state and <i>Trp53</i> -lossDOI 10.1101/2021.02.22.432030Read

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