Article

PI3K activation in neural stem cells drives tumorigenesis which can be suppressed by targeting CREB

2017-05-30

Abstract excerpt

Hyperactivation of the PI3K signaling is common in human cancers, including gliomas, but the precise role of the pathway in glioma biology remains to be determined. Some limited understanding of PI3K signaling in brain cancer come from studies on neural stem/progenitor cells (NSPCs) where signals transmitted via the PI3K pathway cooperate with other intracellular pathways and downstream transcription factors to re...

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Literature Corpus work: 208017b9-8ec9-5ce5-a206-741381fc39ad
DOI: 10.1101/143388

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