Article

GFAP-directed Inactivation of <i>Men1</i> Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

2022-02-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND & AIMS</h4> Efforts to characterize the signaling mechanisms that underlie gastroenteropancreatic neoplasms (GEP-NENs) are precluded by a lack of comprehensive model systems that recapitulate pathogenesis. Investigation into a potential cell-of-origin for gastrin-secreting NENs revealed a role for enteric glia in neuroendocrine cell specification. Here we investigated the hypothe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ef9f661-5a38-5c8d-8b20-fa68a6e8186b
DOI: 10.1101/2022.02.10.479845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GFAP-directed Inactivation of <i>Men1</i> Exploits Glial Cell Plasticity in Favor of Neuroendocrine ReprogrammingDOI 10.1101/2022.02.10.479845Read

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine ReprogrammingSemantic proximity Read

Hedgehog signaling drives glial cell plasticity and oncogenic reprogramming in gastroenteropancreatic neuroendocrine neoplasmsSemantic proximity Read

Menin-MLL Inhibitor MI-503 Blocks Menin Nuclear Export and Suppresses HypergastrinemiaSemantic proximity Read

Tracing Early Molecular Drivers of Gastrinoma in MEN1: A Systematic Review for Precision Surveillance and Improved Patient OutcomesSemantic proximity Read

From diversity to disease: unravelling the role of enteric glial cellsSemantic proximity Read

Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.Semantic proximity Read

Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and modelsSemantic proximity Read

Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous systemSemantic proximity Read

Genome analysis identifies differences in the transcriptional targets of duodenal versus pancreatic neuroendocrine tumoursSemantic proximity Read

Spatial profiling of neuro-immune interactions in gastroenteropancreatic NETsSemantic proximity Read

<i>Ret</i> loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system developmentSemantic proximity Read

Enteric glial cell diversification is influenced by spatiotemporal factors and source of neural progenitors in miceSemantic proximity Read