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Article

Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss.

Neuro-oncology - 4 May 2022

Cases-Cunillera Silvia, van Loo Karen M J, Pitsch Julika, Quatraccioni Anne, Sivalingam Sugirthan, Salomoni Paolo, Borger Valeri, Dietrich Dirk, Schoch Susanne, Becker Albert J

Abstract excerpt

BACKGROUND: Developmental brain tumors harboring BRAFV600E somatic mutation are diverse. Here, we describe molecular factors that determine BRAFV600E-induced tumor biology and function. METHODS: Intraventricular in utero electroporation in combination with the piggyBac transposon system was utilized to generate developmental brain neoplasms, which were comprehensively analyzed with regard to growth using...

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Identifiers

PMID: 34865163
DOI: 10.1093/neuonc/noab268
PMCID: PMC9071348

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