Article
Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling.
Development (Cambridge, England) - 15 Oct 2015
Chen Fuyi, Rosiene Joel, Che Alicia, Becker Albert, LoTurco Joseph
Abstract excerpt
The ability to induce targeted mutations in somatic cells in developing organisms and then track the fates of those cells is a powerful approach both for studying neural development and for modeling human disease. The CRISPR/Cas9 system allows for such targeted mutagenesis, and we therefore tested it in combination with a piggyBac transposase lineage labeling system to track the development of neocortical neural...
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