Article
Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia.
Genomics, proteomics & bioinformatics - 1 Feb 2022
Hong Yaqiang, Zhang Dake, Zhou Xiangtian, Chen Aili, Abliz Amir, Bai Jian, Wang Liang, Hu Qingtao, Gong Kenan, Guan Xiaonan, Liu Mengfei, Zheng Xinchang, Lai Shujuan, Qu Hongzhu, Zhao Fuxin, Hao Shuang, Wu Zhen, Cai Hong, Hu Shaoyan, Ma Yue, Zhang Junting, Ke Yang, Wang Qian-Fei, Chen Wei, Zeng Changqing
Abstract excerpt
Postzygotic mutations are acquired in normal tissues throughout an individual's lifetime and hold clues for identifying mutagenic factors. Here, we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same volunteer as well as the samples from different individuals. In blood, sperm, and muscle cells, we resolved three...
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