Article

Targeted fusion of Antibody-Secreting Cells: unlocking monoclonal antibody production with hybridoma technology

2025-03-19

Abstract excerpt

Monoclonal antibodies (mAbs) produced by hybridoma technology have extensively proved their value for therapeutic, diagnostic, and biomedical research applications, despite the reported low fusion yields between short-lived B cells and immortal myeloma cells. To improve the efficiency of this process and accelerate the development of new mAbs, we characterized and isolated antibody-secreting cells (ASCs) from the...

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Literature Corpus work: 5ef8ab16-6984-5cfb-aaf7-ac504bab804c
DOI: 10.1101/2025.03.19.644155

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