Article
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys.
Scientific reports - 11 Dec 2015
Smith Eric J, Olson Kara, Haber Lauric J, Varghese Bindu, Duramad Paurene, Tustian Andrew D, Oyejide Adelekan, Kirshner Jessica R, Canova Lauren, Menon Jayanthi, Principio Jennifer, MacDonald Douglas, Kantrowitz Joel, Papadopoulos Nicholas, Stahl Neil, Yancopoulos George D, Thurston Gavin, Davis Samuel
Abstract excerpt
Bispecific antibodies, while showing great therapeutic potential, pose formidable challenges with respect to their assembly, stability, immunogenicity, and pharmacodynamics. Here we describe a novel class of bispecific antibodies with native human immunoglobulin format. The design exploits differences in the affinities of the immunoglobulin isotypes for Protein A, allowing efficient large-scale purification....
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