Article

Physicochemical Principles Driving Small Molecule Binding to RNA

2024-02-02

Abstract excerpt

The possibility of using RNA-targeting small molecules to treat diseases is gaining traction as the next frontier of drug discovery and development. The chemical characteristics of small molecules that bind to RNA are still relatively poorly understood, particularly in comparison to protein-targeting small molecules. To fill this gap, we have generated an unprecedented amount of RNA-small molecule binding data, an...

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Literature Corpus work: fdc3a44d-07e2-5d30-b1ee-0cc206cb2f66
DOI: 10.1101/2024.01.31.578268

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