Article

Leveraging Foundation Models for the Characterisation of Small RNA Properties

2026-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Small interfering RNAs (siRNAs) provide a promising therapeutic approach capable of selectively silencing disease-associated genes; however, achieving high efficacy and specificity while minimising off-target effects remains a significant challenge. Endogenous small RNAs, such as microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), exhibit structural features supporting their functions and are...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05f54f77-3a17-52ed-a85b-23f0919fb188
DOI: 10.64898/2026.02.08.704350

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging Foundation Models for the Characterisation of Small RNA PropertiesDOI 10.64898/2026.02.08.704350Read

A generative-AI framework for target-Specific MicroRNAs towards RNAi-based drug designSemantic proximity Read

FENNEC: Fine-Tuned Ensemble Neural Networks Accelerate Chemically Modified siRNA Screening and DesignSemantic proximity Read

siRNADesign: A Graph Neural Network for siRNA Efficacy Prediction via Deep RNA Sequence AnalysisSemantic proximity Read

Capturing Natural Evolution in Function-guided RNA Design via Genomic Foundation ModelsSemantic proximity Read

An RNA foundation model enables discovery of disease mechanisms and candidate therapeuticsSemantic proximity Read

Deep learning predicts non-coding RNA functions from only raw sequence dataSemantic proximity Read

miRAW: A deep learning approach to predict miRNA targets by analyzing whole miRNA transcriptsSemantic proximity Read

Machine learning-guided design of artificial microRNAs for targeted gene silencingSemantic proximity Read

DLRNA-BERTa: A transformer approach for RNA-drug binding affinity predictionSemantic proximity Read

An RNA foundation model enables discovery of disease mechanisms and candidate therapeuticsSemantic proximity Read

MiRformer: a dual-transformer-encoder framework for predicting microRNA-mRNA interactions from paired sequencesSemantic proximity Read

TransfoRNA: Navigating the Uncertainties of Small RNA Annotation with an Adaptive Machine Learning StrategySemantic proximity Read