Article

Accurately modelling RNase H-mediated antisense oligonucleotide efficacy

2025-10-30

Abstract excerpt

Antisense oligonucleotides (ASOs) are a powerful class of drugs with the potential to treat a wide range of human diseases. However, the prediction of ASO efficacy remains challenging, as large-scale and costly experimental screens are typically required to identify optimal candidates for a specific therapeutic target. To address this challenge, we compiled ASO Atlas, a database comprising 188,521 RNase H-mediated...

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Literature Corpus work: 0e6168a7-125b-5680-92e0-9b2c74e72b82
DOI: 10.1101/2025.10.29.685292

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