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Article

Design of antiviral AGO2-dependent short hairpin RNAs

9 May 2024

Abstract excerpt

The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that is triggered by small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs), which exhibits significant promise for antiviral therapy. AGO2-dependent shRNA (agshRNA) generates a single-stranded guide RNA and...

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PMID: 38734183
DOI: 10.1016/j.virs.2024.05.001

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