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Article

Molecular determinants for sodium-dependent activation of G protein-gated K+ channels.

The Journal of biological chemistry - 26 Mar 1999

Ho I H, Murrell-Lagnado R D

Abstract excerpt

G protein-gated inwardly rectifying K+ channels (GIRKs) are activated by a direct interaction with Gbetagamma subunits and also by raised internal [Na+]. Both processes require the presence of phosphatidylinositol bisphosphate (PIP2). Here we show that the proximal C-terminal region of GIRK2 mediates the Na+-dependent activation of both the GIRK2 homomeric channels and the GIRK1/GIRK2 heteromeric channels. Within...

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Source

Identifiers

PMID: 10085101
DOI: 10.1074/jbc.274.13.8639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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