Article

Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia

1998-05-01

Abstract excerpt

Abstract The pathophysiologic role of the Philadelphia chromosome translocation in chronic myelogenous leukemia (CML) has been known for nearly 20 years. However, the most significant morbidity and mortality in CML are caused by progression to blast crisis, about which comparatively little is known at the molecular level. Genomic imprinting is a chromosomal modification leading to parental-origin–specific gene exp...

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Literature Corpus work: 5ead4994-2966-5a8a-aba4-29f6b903a0dd
DOI: 10.1182/blood.v91.9.3144

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