Article
Biallelic expression of the IGF2 gene in human breast disease.
Human molecular genetics - 1 Aug 1996
McCann A H, Miller N, O'Meara A, Pedersen I, Keogh K, Gorey T, Dervan P A
Abstract excerpt
We examined the imprinting status of the insulin-like growth factor II gene (IGF2) in a series of 20 human breast disease samples to determine if disrupted imprinting (as evidenced by biallelic expression), was a demonstrable mechanism of altered gene expression. These samples included benign (n = 7) and malignant breast lesions (n = 13). Biallelic expression of IGF2 was detectable in 67% of benign and 60% of...
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