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Article

Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.

International journal of oncology - 1 Feb 2005

Tessema Mathewos, Länger Florian, Bock Oliver, Seltsam Axel, Metzig Kathleen, Hasemeier Britta, Kreipe Hans, Lehmann Ulrich

Abstract excerpt

H19 and IGF-2 are two growth regulatory genes located on chromosome 11p15 implicated in tumorigenesis. Both genes are imprinted and regulated reciprocally under many circumstances. In order to elucidate the contribution of H19 and IGF-2 to leukemogenesis, the mRNA expression level of both genes were quantitated in bone marrow biopsies and peripheral blood samples from normal (n=98), chronic myelomonocytic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15645136

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.PMID 15645136Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.Semantic proximity Read ↗

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.Semantic proximity Read ↗

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis.Semantic proximity Read ↗

Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.Semantic proximity Read ↗

Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis.Semantic proximity Read ↗

Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma.Semantic proximity Read ↗

The product of the imprinted H19 gene is an oncofetal RNA.Semantic proximity Read ↗

Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors.Semantic proximity Read ↗

Dissociation of IGF2 and H19 imprinting in human brain.Semantic proximity Read ↗

Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.Semantic proximity Read ↗

Loss of imprinting of igf2 in renal-cell carcinomas.Semantic proximity Read ↗

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