Article
Loss of imprinting of IGF-II gene in children with acute lymphoblastic leukemia.
Leukemia research - 1 Sept 2003
Vorwerk Peter, Wex Heike, Bessert Cornelia, Hohmann Bianka, Schmidt Uwe, Mittler Uwe
Abstract excerpt
Insulin-like growth factor-II (IGF-II) is known to be involved in the regulation of growth, differentiation and cell death in normal human tissues. In a variety of human tumors, the IGF-II gene is overexpressed and considered to be a stimulator for tumor growth through autocrine and paracrine mechanisms. The IGF-II gene is normally parental imprinted, only the paternal allele being expressed in most tissues....
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