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Article

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies.

Nucleic acids research - 1 Sept 2014

Sun Jingnan, Li Wei, Sun Yunpeng, Yu Dehai, Wen Xue, Wang Hong, Cui Jiuwei, Wang Guanjun, Hoffman Andrew R, Hu Ji-Fan

Abstract excerpt

Dysregulation of the insulin-like growth factor type I receptor (IGF1R) has been implicated in the progression and therapeutic resistance of malignancies. In acute myeloid leukemia (AML) cells, IGF1R is one of the most abundantly phosphorylated receptor tyrosine kinases, promoting cell growth through the PI3K/Akt signaling pathway. However, little is known regarding the molecular mechanisms underlying IGF1R gene...

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Source

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Identifiers

PMID: 25092925
DOI: 10.1093/nar/gku549
PMCID: PMC4150754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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