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Article

Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia

1 May 1998

Abstract excerpt

The pathophysiologic role of the Philadelphia chromosome translocation in chronic myelogenous leukemia (CML) has been known for nearly 20 years. However, the most significant morbidity and mortality in CML are caused by progression to blast crisis, about which comparatively little is known at the molecular level. Genomic imprinting is a chromosomal modification leading to parental-origin-specific gene expression...

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PMID: 9558368
DOI: 10.1182/blood.v91.9.3144.3144_3144_3147

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