Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

15 May 2015

Abstract excerpt

BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins. To identify potential novel restriction factors, we performed genome-wide scans for human genes sharing molecular and evolutionary signatures of known restriction factors and tested the anti-HIV-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25980612
DOI: 10.1186/s12977-015-0165-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analysesPMID 25980612Read ↗

Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1Semantic proximity Read ↗

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them AllSemantic proximity Read ↗

Novel host restriction factors implicated in HIV-1 replicationSemantic proximity Read ↗

A whole genome screen for HIV restriction factorsSemantic proximity Read ↗

Expression profile of host restriction factors in HIV-1 elite controllersSemantic proximity Read ↗

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeuticsSemantic proximity Read ↗

High content screening and computational prediction reveal viral genes that suppress innate immune responseSemantic proximity Read ↗

Human Immunodeficiency Virus, Restriction Factors, and InterferonSemantic proximity Read ↗

Mechanisms of Immune Evasion in HIV-1: The Role of Virus-Host Protein InteractionsSemantic proximity Read ↗

Restriction Factors in HIV-1 Disease ProgressionSemantic proximity Read ↗

Interdependent Dynamics of mRNA Expression and HIV-1 Viral Load: Insights from Transcriptomics and Mendelian RandomizationSemantic proximity Read ↗

Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.