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Article

Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo

24 Oct 2013

Abstract excerpt

Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected...

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PMID: 24155399
DOI: 10.1128/jvi.02687-13

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