A Ligand-Centered Framework for γδ T Cell Activation in Colorectal Cancer Revealed by Single-Cell and Transformer-Based Perturbation

Abstract excerpt

Understanding the activation mechanisms of γδ T cells in colorectal cancer (CRC) is critical for harnessing their therapeutic potential. Here, using an atlas of human CRC-infiltrating γδ T cells that we built by integrating multiple single-cell RNA-seq datasets, we developed a γδ T cell-refined ligand inference pipeline by combining differential gene expression, gene regulatory network prediction, ligand inference...

Topics

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• Chemokine CCL2
• Colorectal Neoplasms
• Gene Expression Regulation, Neoplastic
• Quantitative Trait Loci
• Receptors, CCR2
• Single-Cell Analysis
• T-Lymphocytes, Regulatory
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

5e509e55-020f-59ed-bf3b-b2dacfc839e7

DOI

10.1101/2025.06.16.660020