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Article

The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis

22 Jun 2021

Abstract excerpt

Abstract CTCF is a key organizer of the 3D genome. Its specialized paralog, BORIS, heterodimerizes with CTCF but is expressed only in male germ cells and in cancer states. Unexpectedly, BORIS-null mice have only minimal germ cell defects. To understand the CTCF-BORIS relationship, mouse models with varied CTCF and BORIS levels were generated. Whereas Ctcf +/+ Boris +/+ , Ctcf +/− Boris +/+ , and Ctcf +/+ Boris...

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PMID: 34158481
DOI: 10.1038/s41467-021-24140-6

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The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesisPMID 34158481Read ↗

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