Article

<i>SPP1</i> <sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

2026-05-03

Abstract excerpt

In chronic inflammatory diseases, maladaptive tissue remodelling is driven by a complex interplay of resident cells, immune filtrates and the extracellular matrix. In the autoimmune disorder rheumatoid arthritis (RA), synovial tissue undergoes assive expansion to form an invasive pannus that drives the erosion of cartilage and bone. The mechanisms mediating this ggressive growth are incompletely defined. Using spa...

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Literature Corpus work: 5e2917a7-ad6e-590d-9db8-60680e7ad182
DOI: 10.64898/2026.04.29.721703

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