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A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

19 Feb 2024

Abstract excerpt

Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTK low CD48 + macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder...

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PMID: 38374174
DOI: 10.1038/s41467-024-45341-9

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