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Article

'PIPs' in DNA polymerase: PCNA interaction affairs.

Biochemical Society transactions - 18 Dec 2020

Acharya Narottam, Patel Shraddheya Kumar, Sahu Satya Ranjan, Kumari Premlata

Abstract excerpt

Interaction of PCNA with DNA polymerase is vital to efficient and processive DNA synthesis. PCNA being a homotrimeric ring possesses three hydrophobic pockets mostly involved in an interaction with its binding partners. PCNA interacting proteins contain a short sequence of eight amino acids, popularly coined as PIP motif, which snuggly fits into the hydrophobic pocket of PCNA to stabilize the interaction. In the...

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PMID: 33196097
DOI: 10.1042/BST20200678

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