Back to search

Article

Specialization for cell-free or cell-to-cell spread of BAC-cloned HCMV strains is determined by factors beyond the UL128-131 and RL13 loci

2019-09-06

Abstract excerpt

<h4>ABSTRACT</h4> It is widely held that clinical isolates of human cytomegalovirus (HCMV) are highly cell-associated, and mutations affecting the UL128-131 and RL13 loci that arise in culture lead to the appearance of a cell-free spread phenotype. The BAC-clone Merlin (ME), expresses abundant UL128-131, is RL13-impaired and produces low infectivity virions in fibroblasts, whereas TB40/e (TB) and TR are low in UL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5e0b0bcc-da5f-54ce-a462-41e66206549b
DOI
10.1101/760611
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Specialization for cell-free or cell-to-cell spread of BAC-cloned HCMV strains is determined by factors beyond the UL128-131 and RL13 lociDOI 10.1101/760611
Specialization for Cell-Free or Cell-to-Cell Spread of BAC-Cloned Human Cytomegalovirus Strains Is Determined by Factors beyond the UL128-131 and RL13 Loci.Semantic proximity
Interstrain recombinants of human cytomegalovirus uncouple glycoprotein display, virion infectivity, and spread characteristics.Semantic proximity
Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131Semantic proximity
Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication.Semantic proximity
Human cytomegalovirus: taking the strain.Semantic proximity
The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus.Semantic proximity
Role of Envelope Glycoprotein Complexes in Cell-Associated Spread of Human Cytomegalovirus.Semantic proximity
HCMV Spread and Cell Tropism are Determined by Distinct Virus PopulationsSemantic proximity
Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131.Semantic proximity
Polymorphisms in Human Cytomegalovirus gO Exert Epistatic Influences on Cell-Free and Cell-To-Cell Spread, and Antibody Neutralization on gH EpitopesSemantic proximity
Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture <i>In Vitro</i>Semantic proximity
Interstrain Recombinants of Human Cytomegalovirus Reveal Complex Genetic Correlates and Epistasis Influencing Glycoprotein Display, Virion Infectivity and Spread CharacteristicsSemantic proximity
Select a neighboring publication to make it the new centre.