Article
The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2017
Murrell Isa, Bedford Carmen, Ladell Kristin, Miners Kelly L, Price David A, Tomasec Peter, Wilkinson Gavin W G, Stanton Richard J
Abstract excerpt
Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire mutations that impact viral growth. These laboratory-adapted strains of HCMV generally exhibit restricted tropism, produce high levels of cell-free virus, and develop susceptibility to natural killer cells. To permit experimentation with a virus that retained a clinically relevant phenotype, we reconstructed a wild-type (WT)...
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