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Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture <i>In Vitro</i>

4 Feb 2016

Abstract excerpt

UNLABELLED: Clinical human cytomegalovirus (HCMV) strains invariably mutate when propagatedin vitro Mutations in gene RL13 are selected in all cell types, whereas in fibroblasts mutants in the UL128 locus (UL128L; genes UL128, UL130, and UL131A) are also selected. In addition, sporadic mutations are selected elsewhere in the genome in all cell types. We sought to investigate conditions under which HCMV can be...

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PMID: 26842472
DOI: 10.1128/jvi.02858-15

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