Article
Role of Envelope Glycoprotein Complexes in Cell-Associated Spread of Human Cytomegalovirus.
Viruses - 2 Apr 2021
Weiler Nina, Paal Caroline, Adams Kerstin, Calcaterra Christopher, Fischer Dina, Stanton Richard James, Stöhr Dagmar, Laib Sampaio Kerstin, Sinzger Christian
Abstract excerpt
The role of viral envelope glycoproteins, particularly the accessory proteins of trimeric and pentameric gH/gL-complexes, in cell-associated spread of human cytomegalovirus (HCMV) is unclear. We aimed to investigate their contribution in the context of HCMV variants that grow in a strictly cell-associated manner. In the genome of Merlin pAL1502, the glycoproteins gB, gH, gL, gM, and gN were deleted by introducing...
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