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Interstrain Recombinants of Human Cytomegalovirus Reveal Complex Genetic Correlates and Epistasis Influencing Glycoprotein Display, Virion Infectivity and Spread Characteristics

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Most of the nucleotide diversity in the human cytomegalovirus (HCMV) genome is due to approximately 17 genes with 2-14 alleles each. These allelic genes are interspersed among longer stretches of highly conserved sequences with signatures of extensive recombination that would shuffle the allelic genes into a vast number of allelic haplotypes. Bacterial artificial chromosome clones derived from 3...

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Literature Corpus work
0786d592-2428-5ee6-b01b-07ab823786ae
DOI
10.1101/2025.09.22.677782
Open publication

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