Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer.

doi:10.1158/1078-0432.CCR-24-1166

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Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2024

Lee Hey Min, Saw Ajay Kumar, Morris Van K, Napolitano Stefania, Bristow Christopher, Srinivasan Sanjana, Peoples Micheal, Sorokin Alexey, Kanikarla Marie Preeti, Schulz Jonathan, Singh Anand K, Terranova Christopher, Coker Oluwadara, Jain Abhinav, Kopetz Scott, Rai Kunal

Abstract excerpt

PURPOSE: BRAFV600E-mutated colorectal cancer exhibits a strong correlation with DNA hypermethylation, suggesting that this subgroup of tumors presents unique epigenomic phenotypes. Nonetheless, 5-azacitidine, which inhibits DNA methyltransferase activity, is not efficacious in BRAFV600E colorectal cancer in vivo. EXPERIMENTAL DESIGN: We randomized and treated mice implanted with patient-derived tumor xenografts...

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PMID: 39269307
DOI: 10.1158/1078-0432.CCR-24-1166

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