Article

Targeted <i>Tshz3</i> deletion in corticostriatal circuit components segregates core autistic behaviors

2021-10-15

Abstract excerpt

We previously linked TSHZ3 haploinsufficiency to autism spectrum disorder (ASD) and showed that embryonic or postnatal Tshz3 deletion in mice results in behavioral traits relevant to the two core domains of ASD, namely social interaction deficits and repetitive behaviors. Here, we provide evidence that cortical projection neurons (CPNs) and striatal cholinergic interneurons (SCINs) are two main and complementary...

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Literature Corpus work: 5df04088-d4f6-502c-b177-8eb92374d702
DOI: 10.1101/2021.10.15.464549

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Targeted <i>Tshz3</i> deletion in corticostriatal circuit components segregates core autistic behaviorsDOI 10.1101/2021.10.15.464549Read

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